Clomid vs. Nolvadex in the treatment of infertility

Early studies comparing Nolvadex to Clomid for the treatment of infertility have shown that the two drugs may be equally effective in leading to pregnancy. In addition, Nolvadex may be less likely to cause problems with the cervical mucus and thickness of the uterine lining. However, healthcare providers may be more likely to prescribe Clomid, since it has been studied longer as an infertility treatment.


Nolvadex (tamoxifen citrate) is a prescription medication used to prevent and treat breast cancer. It is part of a group of medications called selective estrogen receptor modulators (SERMs). Clomid (clomiphene citrate) is a prescription medication that is used as an infertility treatment in women.

Early studies have shown that Nolvadex may be as effective as Clomid for treating infertility.

Comparing Nolvadex to Clomid: What Does the Research Say?
Several small studies have compared Clomid versus Nolvadex for treating infertility. Most of these studies have shown that the two drugs are equally likely to lead to pregnancy.

Nolvadex may be less likely to cause negative effects on cervical mucus and the thickness of the uterine lining when compared to Clomid. Although Clomid is usually effective at inducing ovulation, it can also cause problems with cervical mucus and the lining of the uterus (which may explain why some women ovulate on Clomid but do not become pregnant).

Clomid Versus Nolvadex: Final Thoughts
Many healthcare providers are more comfortable prescribing Clomid for infertility, as it has been thoroughly studied and has been used for decades to treat the condition. However, Nolvadex appears to be a promising infertility treatment and may be an option in women for whom Clomid has not been successful.